Eli Lilly has today forecast strong profit growth for 2026 on the back of surging obesity drug demand, shaking off pricing pressures that helped sink rival Novo Nordisk’s outlook.
Lilly last year became the first pharmaceutical company to hit a $1 trillion valuation, driven by the popularity of its weight-loss drug, Zepbound, in a rapidly expanding obesity market that is seeing newer avenues to bolster growth.
Lilly forecast a 2026 profit of $33.50 to $35 per share, with the low end of the range above analysts’ average estimate of $33.23, according to LSEG data. It projected full-year sales of $80 billion to $83 billion, well ahead of Wall Street estimates of $77.62 billion.
In contrast, Danish drugmaker Novo Nordisk this week warned of “unprecedented” price pressures in 2026, particularly in the US, rattling investors with a forecast for a steep sales drop this year.
For the fourth quarter, Lilly reported a profit of $7.54 per share. Analysts were expecting $6.67. Revenue rose to $19.3 billion, ahead of Wall Street expectations of $17.96 billion.
The strong quarter and outlook “reminds us that while Lilly and Novo play in the same markets, the pressures they face are not identical,” said BMO Capital analyst Evan Seigerman.
Investor focus is squarely on how Lilly will navigate mounting pricing pressure after its deal with the Trump administration, which promised steep price cuts for its obesity treatments for the government Medicare and Medicaid programs and for cash payers.
Sales of diabetes drug Mounjaro, which has the same active ingredient as Zepbound, came in at $7.41 billion for the fourth quarter, compared with analysts’ expectations of $6.63 billion.
Zepbound recorded sales of $4.3 billion for the quarter, above estimates of $3.41 billion.
The company said US sales for Zepbound were driven by volume, offset by some price decreases, and that international sales of Mounjaro, the branded name for both diabetes and weight-loss medication outside the US, were driven primarily by volume.
Novo’s Wegovy and Lilly’s Zepbound, which initially retailed for about $1,000 a month at US pharmacies, are now sold on company websites for starting prices of $199 to $299 after political pressure to lower costs.
Cantor analyst Carter Gould said the new forecast should help assuage fears over whether market expansion can drive meaningful growth despite pricing pressures.
“The high-end, the low-end, the narrower guide – all of it – express a far more confident view of the market than most of the Street were anticipating,” he said.
Novo warned that its similar agreement with the US government will shave 2% to 4% off revenue this year, while Lilly said higher patient volumes should help cushion that blow.
Focus is also building around the expected launch of Lilly’s oral weight-loss drug, orforglipron, seen as an important future growth driver. The pill is under US FDA review, with a decision expected in April. Novo recently began selling an oral version of its Wegovy.
Both companies have been moving aggressively in the cash-pay market.
Novo is selling lower doses of its daily pill in the US for $149 a month, rising to $199 from April.
Lilly has said it plans to cap the price of higher doses of its obesity pill, if approved, at $399 a month for repeat cash-paying patients.
